Categoria: Tradução

  • Faculty members

    Faculty members

    profa christine

    Angélica Ribeiro Soares, PhD

    Chemistry of Natural Products from Marine and Freshwater Marine Organisms; Pharmacological Activity Evaluation of Natural Products of Aquatic Organisms; Physiological and Ecological Aspects of Natural Products of Aquatic Organisms.

    Contact:  angelica.r.soares@gmail.com

    Lattes

    Bertira Bergmann
    Bartira Rossi Bergmann, PhD
    Biotechnological development of oral or intranasal antileishmanial vaccines. Development of antileishmanial drugs for topical and oral use. Use of nanotechnology to improve drugs and vaccines. Investigation of the antianaphylactic mechanism of Kalanchoe pinnata.

    Contact: bartira@biof.ufrj.br 

    Lattes

    prof rangel

    Carlos Rangel Rodrigues, PhD

    Molecular modeling, QSAR and in silico pharmacokinetic and toxicological studies of bioactive compounds


    Contact: rangel@pharma.ufrj.br 

    Lattes

    felipe paleol
     Chaquip Daher Netto, PhD
     Synthesis of antitumor, antiparasitic and antimicrobial quinones, Identification, planning, synthesis, development and biological activity of bioactive products.

     

    Contact: chaquip@gmail.com 

    Lattes

    Cintia Monteiro

    Cintia Monteiro de Barros, PhD

    Neuroimmunological regulation; Biochemical and morfological aspects of regeneration central nervous system; Regulation of Invertebrates immune system; Study comparative, morfological and functional of the invertebrate hemocytes; Toxicology studies using invertebrates as models; Glycosaminoglycans and neurodegenerative diseases.

    Contact:  cintiabarros@macae.ufrj.br

     Lattes

    Diego PaschoalDiego Fernando da Silva Paschoal, PhD

    Nonlinear Optical Properties Calculation of Molecules with Potential Technological Application; Development of Atomic Basis Sets; Computational Study of Transition Metal Complexes with Antineoplastic Potential; Theoretical Prediction of Nuclear Magnetic Resonance Parameters; Synthesis and Characterization of Coordination Compounds with Potential Biological Application.

    Contato:diegopaschoal01@gmail.com | diegofspaschoal@macae.ufrj.br

    Lattes

    prof heitor copia

    Eldo Campos, PhD
    Molecular Systems and Therapeutic Targets, Mitochondrial Arthropod Bioenergetics.

    Contact:  eldocampos@macae.ufrj.br

    Lattes

    Ivana Leal

    Ivana Correa Ramos Leal, PhD

    Brazilian medicinal plants with antimicrobial activity, multiresistant hospital bacteria, enzymatic biocatalysis, chemical reactions and extractions in microwave reactors, analytical methodologies.

    Contact:  ivanafarma@yahoo.com.br

    Lattes

    prof jorge
    Jackson de Souza Menezes, PhD

    Ion channel expression throughout the nephron, Tissue bioengineering, Nephrotoxicology, Wild rodent renal physiology and Comparative animal physiology.

    Contact:  jacksonmenezes@gmail.com

                                 Lattes

    Joao Wanderley
    João Luiz Mendes Wanderley, PhD
    Immunoparasitology, acting mainly on infectious diseases, regulation of innate immunity, cell death and inflammation.

    Contact: lmwjoao@macae.ufrj.br 

    Juliana Montani

    Juliana Montani Raimundo, PhD
    Pharmacological evaluation of bioactive products in vascular smooth muscle. New strategies for prevention and / or treatment for obesity-related vascular dysfunction and diabetes mellitus.

    Contact: julianamontani@macae.ufrj.br 

    Lattes

    prof mario copia

    Magdalena Nascimento Rennó, PhD

    Evaluation of the pharmacological activity of bioactive compounds of natural, synthetic or semi-synthetic origin with anticancer and antiparasitic activities, and for neurodegenerative diseases or others disorders; Enzyme inhibitor studies using molecular modeling; Rational use of medicines.

    Contact: mnrenno@macae.ufrj.br 

    Lattes

    marco antonio cruz

    Maximiliano da Silva Sangoi, PhD

    Industrial Pharmacy; Development and validation of analytic and bioanalytic methods through liquid chromatography, capillary electrophoresis and mass spectrometry for bioequivalence studies and quality control of medicines, with emphasis on the identification of degradation products.

    Contact: ms.sangoi@macae.ufrj.br 

    Lattes

    Michelle Muzitano
    Michelle Frazão Muzitano, PhD
    Study of Plant Species of Jurubatiba Restinga (Macaé-RJ) as Source of New Antimicobacterial Drugs. Vegetal Species of Jurubatiba Restinga (Macaé-RJ) as a Source of New Vasodilator Drugs. Study of antimicobacterial and anti-inflammatory activities of natural products and their analogues aiming at dual treatment of severe tuberculosis.

    Contact: mfmuzitano@macae.ufrj.br 

    Lattes

    Nelilma Romeiro

    Nelilma Correia Romeiro, PhD

    Chemogenomics Studies and Molecular Modeling of Bioreceptors and Potential Drugs Obtained from Natural Products and Organic Synthesis.

    Contact: nelilmaromeiro@macae.ufrj.br 

    Lattes

    prof Paula Alvarez

    Paula Alvarez Abreu, PhD

    Molecular modeling in the study of therapeutic targets and drug designing. Antifungal and antibacterial activity tests of new synthetic derivatives.

    Contact: abreu_pa@yahoo.com.br 

    Lattes

    Paulo Costa

    Paulo Roberto Ribeiro Costa, PhD

    Designing and synthesis of cytotoxic substances with potential anticancer, antiviral and antiparasitic actions. Designing and synthesis of phospholipase and protease inhibitors. Study of substances with potential antiophidic, antiinflammatory and cytoprotective action. Designing and synthesis of free radical traps. Study of substances with potential cytoprotective and antiinflammatory action. Development of new synthetic strategies for obtaining bioactive substances. Design and synthesis of enzyme inhibitors: NS5B (RNA polymerase, hepatitis C) and NH (nucleoside hydrolase, Leishmanis sp.). Planning and synthesis of substances with potential action on the central nervous system.

    Contact: prrcosta@nppn.ufrj.br 

    Lattes

    rodrigo

    Rodrigo Nunes da Fonseca, PhD

    Molecular biology, Gene silencing, Functional genomics, Identification of drug development targets.

    Contact: rnfonseca@macae.ufrj.br 


    Lattes, ResearcherID, Evo-Devo WP

    Rosane Ribeiro

    Rosane Aparecida Ribeiro, PhD

    Regulation of endocrine pancreatic function by amino acids. Regulation of insulin and glucagon secretion and action in obesity and diabetes. Amino acid supplementation as an alternative to the treatment of obesity and diabetes.

    Contact: rosaneribeirobio@macae.ufrj.br 

    Lattes

    prof Paula Alvarez

    Thiago Barth, PhD

    Development of conventional and enantioselective chromatographic methods (HPLC, GC) for analysis of natural and synthetic products and their metabolites in different matrices; Metabolism studies with liver microsomes and fungal biotransformation of bioactive natural and synthetic products; Development of conventional (liquid-liquid and solid phase extraction) and miniaturized (HF-LPME, DLLME and SPME) methods for drug, natural products and its metabolites extraction from complex matrices.

    Contact: thiagobarth@macae.ufrj.br 

    Lattes

    prof Paula Alvarez

    Thiago da Silveira Alvares, PhD

    Dr. Alvares’s research program focuses on improving cardiovascular function through food, with an emphasis on macrovascular endothelial function and microvascular reactivity. His laboratory is currently investigating nutrients such as L-arginine, nitrate, and L-citrulline; foods such as beetroot, watermelon, fish; and other compounds that are found in dietary supplements such as garlic, capsaicin, and curcumin. Using the human model, we are learning about the mechanisms by which macrovascular endothelial function and microvascular reactivity can be modified by food. The goal is to improve cardiovascular function by reducing the detrimental effects associated with macrovascular and microvascular endothelial dysfunction.

    Contact: alvares@macae.ufrj.br  or gpnutmex.ufrj@gmail.com

    Lattes

     

  • Areas of research

     

    Areas of research

     

        In the perspective of the area of training introduced, PPGProdBio has two broad areas of research:

     

    Identification, Planning, Synthesis, Development and Biological Activity of Bioactive Products.


       In the context of this area of research, the bioactive compounds will be obtained through isolation of natural products and synthetic pathways so that they can be later analyzed in vitro, in vivo and also ex vivo.

      The biological assessment is done by means of pharmacobotanical and ethnobotanical approaches, application of techniques of molecular modelling QSAR 2D and 3D, application of crystallography techniques, nuclear magnetic resonance, molecular dynamics and model simulation in the planning of drugs, application of pharmaceutical nanobiotechnology aiming at the technological development of bioactive products, including skin cosmetics, conventional pharmaceutical forms and nanoencapsulated systems, study of bioavailability and of pharmaceutical bioequivalence and equivalence, food-drug interactions and foods with functional properties.

     

    Molecular Systems and Therapeutic Targets


       This area of research aims to investigate the workings of cells, tissues and in vivo in the most varied physiological and pathological processes, including the response/signal pattern of these cells to various (intra and extracellular) stimuli in order to develop therapeutic target models to be used in the assessment of bioactive products and advanced therapies; production, isolation, and purification of proteins and biomacromolecules; development and production of biomacromolecules ; biotransformations and enzymatic synthesis of drugs; development of kinetic enzymatic methods; virus vectors; cellular therapies.

  • Disciplines

    Disciplines

     

        In order to obtain the title, our Master’s candidates must complete three required courses, besides some elective ones, which can be taken in the same institution or in another facility. In addition, candidates must develop their experimental dissertation work, which is computed in the course Dissertation Experimental Work. The candidate needs 360 hours in activities. The required courses are: Didactic Activities, Scientific Method and Bioscience I.

        We currently offer the courses listed below. Future courses will be closely related to the research projects and research lines of PPGProdBio.

     

    REQUIRED COURSES TO OBTAIN THE TITLE OF MASTER
    ID DISCIPLINE
    MCF 701  Scientific Method
    MCF 702  Seminar in bioactive products and bioscience I             
    MCF 703  Didactic activities I

     

    REQUIRED COURSES TO OBTAIN THE TITLE OF MASTER

             ID        

    DISCIPLINE
    MCF 704

     Gliomas: therapeutic models

    MCF 705

     Basic neurobiology and neuropathology

    MCF 706

     Mechanisms involved in anti-inflammatory and antitumor activity of bioactive compounds

    MCF 707

     Biological assays

    MCF 708

     Topics in molecular modelling applied to bioactive products

    MCF 709

     Studies in metabolism and toxicokinesis  using computer resources

    MCF 710

     Cellular and molecular aspects of chronic kidney failure and new therapeutic approaches

    MCF 711

     Advanced topics in Pharmacology

    MCF 712

     Advanced topics in Metabolism and Bioenergetics

    MCF 713

     Advanced topics in Organic Chemistry

    MCF 714

     Structure of Organic compounds

    MCF 715

     Quality control of efficacy and safety of medicines

    MCF 716

     Development and characterization of disperse systems

    MCF 717

     Technological development of phytotherapeutic products

    MCF 718

     Biosynthesis of Secondary Metabolites in Plants

    MCF 719

     Basics of regulation of food intake: obesity and drugs development

    MCF 720

     Purification of Bioproducts

    MCF 721

     Industrial application of Enzymes

    MCF 722

     Molecular Biology and Functional Genomics

     

    MCF 723

     Physiopathology, embryo development and control strategies of arthropods which are vectors of tropical diseases

    MCF 724

     Bioinorganic Chemistry

    MCF 725

     Vibration Spectroscopy

    MCF 726

     Applied Biostatistics

    MCF 727

     Congresses I

    MCF 728

     Dissertation Research

    MCF 729

     Scientific Advising I

    MCF 730

     Scientific Advising II

    MCF 731

     Introduction to natural and bioactive products

    MCF 732

     Glycoconjugates’ structure

    MCF 733

     Biological roles of Glycans

    MCF 734

     Introduction to Intellectual Property

    MCF 735

     Control of Energy Metabolism

    MCF 736

     Introduction to Genetic Engineering

    MCF 737

     Congresses II

    MCF 738

     Biology of Vector Arthropods

    MCF 739

     Special topics in bioactive Products I

    MCF 740

     Special topics in bioactive Products II

    MCF 741

     Seminars in Bioactive Products and Bioscience II

    MCF 742

     Importance of Heterocycles

    MCF 743

     Polymer Chemistry

    MCF 744

     Surface and Colloid Chemistry

    MCF 745

     Development of vaccines

    MCF 746

     Chromatographic methods and Capillary Electrophoresis